Parvovirus B19 A Case Report And Review Of The Literature

Parvovirus B19 in a renal allograft: A case report and review of the literature. Oramas DM., Patel T., Setty S., Yeldandi V., Cabrera Abstract: Parvovirus B19 infection in solid organ transplanted recipient is an underdiagnosed entity. It is usually responsible for unexplained acute and chronic red blood cell aplasia not responding to erythropoietin therapy. Cases of Parvovirus B19 infection associated with pancytopenia, solid organ dysfunction, and allograft rejection have been also described in the literature. Deterioration of the immune system as a result of the severe immunotherapy favors reactivation of an old infection or acquirement of a new one. We present a case of a 32-year-old woman with one-year history of renal allograft transplant and previous cytomegalovirus infection who presented with chest pain, polyarthritis, pancytopenia and renal dysfunction. Serology for Parvovirus showed a titer of 13.8 trillion IU/ml and CMV 800 IU/ml. Renal biopsy revealed nucleomegaly with focal viral inclusions, along with changes associated with immunotherapy toxicity. Electron microscopy showed capillary and tubular epithelial ce lls â€Å"viral factories† confirming the diagnosis. We conclude that screening for parvovirus B19 should be advised in high risk cases who present with refractory anemia to avoid complication of the chronic infection as fatal rejection of the transplanted organ. Key words: Parvovirus B19, renal allograft, transplant Parvovirus B19 is the predominantShow MoreRelatedPodiatry Rhuematoid Arthritis8124 Words   |  33 Pagesquote its cause as unknown (Adams et al.2008, Maggi 2012). Genetic (tabulated in Figure.1) and environmental factors (for example smoking and pathogenic bacterium) interact (Klareskog 2006, Too 2012). Genetic Involvement Author/s Critique of Literature Genes associated with expression Major Histocompatability Complex (MHC) Presence of the human leukocyte antigens or (HLA) ‘share-epitope’ alleles Newton et al 2004, Plenge et al 2007, Steer 2009, Too et al 2012 Strong evidence behind HLA involvement